A blog about golf course architecture Friday, May 18, The opening shot at Tobacco Road -intimidation at its best – there’s lots of room beyond the dunes Best Course: The people that really like his work actively seek out all his courses and interestingly enough many are the younger architects in the ASGCA. He embodies the idea that the line between genius and madman is razor thin — often stepping on both sides with delightful results. No matter what you think of his work, there is no denying his superior talent, and his guts to push golf course architecture to its very limits. Praise for the work: I have never seen an architect combine intimidation and opportunity so masterfully. He believes that you get a bigger thrill when you make a great shot that seemingly overcomes impossible odds — he does this by making his work look overwhelming at times but in reality is a lot easier than it appears. While most would point to the intentional blindness and very wild greens to say that his work is over the top, they have missed his use of width to create playability and alternative safer routes.

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In late , a two-door coupe was introduced in Japan. Initial engine choices included 1. Subaru chose to continue their longstanding use of the boxer engine in the Impreza. According to Subaru, their configuration of the engine inline with the transmission minimizes body roll due to the lower center of gravity compared with offset engines in most other vehicles.

United Greek Council. The United Greek Council, commonly referred to as UGC, is the governing body for the five multicultural and special interest based sororities and fraternities at Georgia College.

Career Highlights Season Claimed six top finishes, two of which were top showings. Made 11 of 13 cuts en route to qualifying for the FedExCup Playoffs for the 10th time. Closed out the season in style, captaining the United States to an eight-point victory in the Presidents Cup. Pulled all the right strings in his debut as the United States Captain at the Presidents Cup, leading his team to a dominating victory over the International squad at Liberty National.

Was one of three players to finish T3 at the 3M Championship in August. Made just one bogey over his final 52 holes and a second-round 9-under-par 63 helped his cause. After making the hole cut on the number of 2-under , posted scores of 6-under 65 and 7-under 64 in rounds three and four, respectively, to finish T5 at the John Deere Classic with four others, including Zach Johnson.

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Woolsthorpe, England, 25 December ; d. London, England, 20 March mathematics, dynamics, celestial mechanics, astronomy, optics, natural philosophy. Isaac Newton was born a posthumous child, his father having been buried the preceding 6 October. Newton was descended from yeomen on both sides: He was born prematurely, and there was considerable concern for his survival.

In past years, in addition to large on-campus events such as the Gargoyle Gala, GC-sponsored events have included bowling nights, First Fridays at the MCA, ice skating on the midway, Pritzker’s speed dating event, as well as many others.

Abstract Drug discovery and development is a labor-intensive and timeconsuming process that comes with a significant price tag. Mass spectrometry MS technology has evolved to the point where it is used throughout the drug development process, and now plays a key role in advancing the production of pharmaceuticals. In particular, when MS is coupled with a chromatographic separation technology, it becomes a powerful analytical tool, which adds an orthogonal detection function for sample analysis, and provides information-rich assessment of pharmaceutical compounds.

This review describes the strategies and current approaches for MS and hyphenated MS in supporting of small molecule drug development. It also highlights the latest developed instrumentation and software that has great potential to expand the utility of MS for pharmaceutical development. Introduction In spite of the great progress made in research and development to combat severe diseases such as cancer, rheumatoid arthritis, high blood pressure, and aging-associated diseases, the drug development process itself has become increasingly complex and expensive.

It is estimated that only one drug reaches market approval for every new chemical entities evaluated in a discovery program. Drug development generally includes four major stages: The longest stage is typically clinical development, which encompasses the testing done in humans i. This in part can be attributed to the regulatory requirements in drug development, which limits the development and acceptance of novel methods3. With the recent development in both software and instrumentation, MS techniques have been well adapted and are now the preferred choice for many applications in pharmaceutical development4,5.

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The Bank of Canada is responsible for setting monetary policy in Canada, targeting inflation through manipulation of overnight interest rates i. It oversees major clearing and settlement systems, providing those systems with banking services pursuant to the Payment Clearing and Settlement Act ; promotes financial stability globally with international bodies; and provides liquidity to the financial system.

The Bank of Canada is also responsible for issuing currency. Some of the primary risks concerning the Bank of Canada include the safety, soundness, stability and efficiency of the financial system. FRFIs include all banks in Canada as well as all federally incorporated or registered trust and loan companies, insurance companies, cooperative credit associations, fraternal benefit societies and private pension plans.

Reddit gives you the best of the internet in one place. Get a constantly updating feed of breaking news, fun stories, pics, memes, and videos just for you. Passionate about something niche? Reddit has thousands of vibrant communities with people that share your interests. Alternatively, find out what’s trending across all of Reddit on r/popular.

They are considered promising because they can be derived from biological matter via established and new processes. In addition, many of their physical-chemical properties are compatible with the requirements of modern engines, which make them attractive either as replacements for fossil fuels or as fuel additives.

Indeed, alcohol fuels have been used since the early years of automobile production, particularly in Brazil, where ethanol has a long history of use as an automobile fuel. Recently, increasing attention has been paid to the use of non-petroleum-based fuels made from biological sources, including alcohols predominantly ethanol , as important liquid biofuels. Today, the ethanol fuel that is offered in the market is mainly made from sugar cane or corn.

Its production as a first-generation biofuel, especially in North America, has been associated with publicly discussed drawbacks, such as reduction in the food supply, need for fertilization, extensive water usage, and other ecological concerns. More environmentally friendly processes are being considered to produce alcohols from inedible plants or plant parts on wasteland. While biofuel production and its use especially ethanol and biodiesel in internal combustion engines have been the focus of several recent reviews, a dedicated overview and summary of research on alcohol combustion chemistry is still lacking.

Besides ethanol, many linear and branched members of the alcohol family, from methanol to hexanols, have been studied, with a particular emphasis on butanols. These fuels and their combustion properties, including their ignition, flame propagation, and extinction characteristics, their pyrolysis and oxidation reactions, and their potential to produce pollutant emissions have been intensively investigated in dedicated experiments on the laboratory and the engine scale, also emphasizing advanced engine concepts.

Research results addressing combustion reaction mechanisms have been reported based on results from pyrolysis and oxidation reactors, shock tubes, rapid compression machines, and research engines.

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The Complexities and Problems of Periodization Theory Introduction To Periodization Many articles posted online about training periodization revolve around how to set up your training to “bust through plateaus” and hit your “biggest PRs ever”. While periodization certainly does help you in doing both, many authors neglect to write about the “whys” and are inconsistent when using training terminologies. What’s the difference between linear and daily undulating DUP?

I thought blocks were called phases? How do I linearly progress man? A lot of terms get thrown around without proper context, and unless you have some background in exercise science or an in-depth understanding of exercise physiology, it can get confusing.

Being rammed by larger ships since Let’s play a game: Which of these words do you think triggered the site’s filter to redirect me to a dumb shitpost on YouTube, and why do you think none of the other posts in this thread met the same fate?

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Mass spectrometry

Age of the Universe There are at least 3 ways that the age of the Universe can be estimated. I will describe The age of the chemical elements. The age of the oldest star clusters. The age of the oldest white dwarf stars. The age of the Universe can also be estimated from a cosmological model based on the Hubble constant and the densities of matter and dark energy.

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Registration and complementary breakfast 9: Welcome and introductions 9. Complimentary networking lunch 1;30 PM With a focus on HL7 and data mining, Caristix software makes it simpler and faster for hospitals and vendors to deliver interfaces that support the flow of data in healthcare. EDO Mobile Health www. It is a secured and private environment for families that provides the necessary tools to help care for a loved one. The centralized repository allows guideline developers to work collaboratively and manage the entire lifecycle of a guideline, while integrated approval-routing ensures adherence to regulatory compliance and quality standards.

We remove all technology barriers so that the our clients can focus on improving patient outcomes, increasing efficiency and translating engagement into cost-savings. Through an elegant control panel, our clients can build their mobile health apps without any programming skills whatsoever. The business model is based on deploying software as a service, and monetizing from the immense potential of collecting health data which produces analytics of interest to pharmaceutical companies, insurance companies, market research organisations and government.

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